You can translate with "Che succede?".I'd have an english-italian translation!?
If you mean, "How do you say, 'What's up?' in Italian?", I think it's "Come butta?", or more fully, "Come butta patata?" ("How does the potato throw?")I'd have an english-italian translation!?
do you means the italian meaning for "what's up"?
if so, in italian we would say "come va" which literally means "how's it going" which is technically what what's up means in english anyways.
I'm italian so i could help you.. but what do you exactly mean for that?